Enantioselective organocatalytic aldehyde–aldehyde cross-aldol couplings. The broad utility of a-thioacetal aldehydes
نویسندگان
چکیده
An asymmetric proline catalyzed aldol reaction with a-thioacetal aldehydes has been developed. Thioacetal bearing aldehydes readily participate as electrophilic cross-aldol partners with a broad range of aldehyde and ketone donors. High levels of reaction efficiency as well as diastereoand enantiocontrol are observed in the production of anti-aldol adducts. q 2004 Elsevier Ltd. All rights reserved.
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